Special Report on Cancer: From mutations to metabolism with spatial-omics

The importance of single-cell technologies to cancer research cannot be minimized. Methodologies like single-cell sequencing and mass cytometry have helped elucidate the scale and implications of tumor heterogeneity, as well as the role of non-tumor cells in cancer evolution and progression. But in isolating these cells to understand their functions and diversities, researchers have lost a critical factor of human disease: context.