Vizgen Events

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Day 2 track 1 – 09.55-10.25

Title: Improved spatially resolved single cell transcriptomic imaging in archival tissues with MERSCOPE® and MERSCOPE® Ultra.

Abstract:
In this presentation we will discuss an enhanced MERFISH chemistry and workflow to perform MERFISH across a broad range of sample qualities, and introduce the MERSCOPE Ultra Platform.

ABSTRACT
Leveraging advancements in spatially resolved single-cell profiling, our study enhances understanding of glioma evolution and the complex tumor microenvironment. Through spatially resolved multi-omic analysis of glioma samples from different treatments and stages, we've mapped glioblastoma's architectural changes over time, highlighting mechanisms behind therapy resistance. Our use of array-based and in-situ transcriptomics across treatment types revealed key transcriptional programs related to resistance, showing significant inter-patient heterogeneity and unique resistance pathways in recurrent tumors. We identified adaptations in the neural and immune microenvironment shifts post-immunotherapy, indicating mechanisms of resistance development. By integrating spatial transcriptomics and clinical data into graph-neural networks, we've created models predicting treatment responses, offering new insights for precision oncology.