Events

June 10
1:00pm ET
GABA-receptive microglia selectively sculpt developing inhibitory circuits
Webinar
Microglia, the primary brain macrophages, regulate a plethora of processes that impact the organization of neural circuits, including synapse pruning. Whether microglia are generic effectors of synapse pruning or if specialized microglia are able to discriminate between distinct synapse types is unknown. We found that GABA-receptive microglia selectively interact with inhibitory cortical synapses during a critical window of mouse postnatal development. Single cell RNA-seq and MERFISH profiling showed that ablation of microglial GABAB receptors cell-autonomously alters a transcriptional synapse remodeling program. As a result, loss of GABABRs within microglia alters inhibitory connectivity without impacting excitatory synapses and leads to behavioral abnormalities. These findings demonstrate that distinct microglia differentially engage with specific synapse types during development.
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JAN 11-15
Biotech Showcase Digital
Online
Mar 1-3
10AM
AGBT General Meeting
Virtual
Mar 11-12
VIB's Revolutionizing Next-Generation Sequencing (Virtual 4th edition)
Virtual
April 14-16
Spatial Biology Europe
Online
April 20-22
Genetics Virtual Week 2021-LabRoots
Virtual
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