Vizgen is developing the next generation of genomics tools to expand on the capabilities of spatially resolved transcriptomics. Our technology will aide the acceleration of biological research and discovery to advance human health. Access supporting resources by selecting the category below.
Like detective work, detailed understanding of the complexities of biological systems requires scientists to answer questions about details at every level: what, when, why, how…and where. Spatial genomics, Nature’s 2020 Method of the Year, can…
Single-cell sequencing has provided numerous novel insights into cell heterogeneity and cell-type-specific adaptation of the nervous system. However, most sequencing-based techniques require cell dissociation and consequently lose the spatial information of the analyzed cells, which…
Our understanding of molecular biology and pathology has been greatly facilitated by recent advances in multiple sequencing technologies, coupled with computational analysis, to detect and count proteins and transcripts. However, these tools lack spatial resolution…
Spatial omics techniques generate spatially resolved, comprehensive data about molecules that define the identity and function of cells in tissues. Epigenetic multiplexing approaches such as Multiplexed Error-robust FISH (MERFISH), introduced by Lu et al. in this…
Abstract Models of intercellular communication in tissues are based on molecular profiles of dissociated cells, are limited to receptor–ligand signaling and ignore spatial proximity in situ. We present node-centric expression modeling, a method based on…
Abstract The recent development of spatial omics methods has enabled single-cell profiling of the transcriptome and 3D genome organization with high spatial resolution. Expanding the repertoire of spatial omics tools, a spatially resolved single-cell epigenomics…
Formalin-fixed paraffin-embedded (FFPE) tissues are widely used clinical sample types for histology and molecular diagnosis. However, due to RNA degradation and protein cross-linking, FFPE samples are often challenging for single-cell transcriptomic analysis. Vizgen’s in situ…
Spatial transcriptomics extends single cell RNA sequencing (scRNA-seq) technologies by providing spatial context for cell type identification and analysis. In particular, imaging-based spatial technologies such as Multiplexed Error-Robust Fluorescence In Situ Hybridization (MERFISH) can achieve…
The olfactory system’s ability to detect and discriminate between the vast array of chemicals present in the environment is critical for an animal’s survival. In mammals, the first step of this odor processing is executed…
Abstract: Spatially resolved transcriptomic imaging technologies such as Vizgen’s MERSCOPE TM platform allows massively multiplexed single-cell measurement in situ and have been instrumental for molecular and cell atlasing. However, cell types and states are not only…