Publications
Abstract: MERFISH (multiplexed error-robust fluorescence in situ hybridization) is a novel single-cell transcriptomics technology that captures spatial gene expression patterns across whole tissue slices with sub-cellular resolution.1 However, it can be difficult for researchers to…
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Product Literature
MERSCOPE FFPE Data Advantages • High reproducibility between matched fresh frozen and formalin fixed paraffin embedded tissue samples ensures biologically impactful data • Unmatched accuracy with bulk RNA-sequencing data across the entire expression profile provides…
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Application & Technical Notes
A New Spatial Transcriptomics Technique Accurately Reveals the Organization of The Mouse Brain Transcriptome This application note describes how the MERFISH Mouse Brain Receptor map was generated by MERSCOPE and demonstrates how the platform can…
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Videos
Learn how Multiplexed Error-Robust Fluorescence in situ Hybridization (MERFISH) technology works. MERFISH is a spatially resolved single-cell transcriptome profiling technology. MERFISH combines the power of single-cell transcriptomics with spatial biology by directly visualizing and counting…
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Publications
I-Hao Wang, Evan Murray, Greg Andrews, Hao-Ching Jiang, Sung Jin Park, Elisa Donnard, Violeta Durán-Laforet, Daniel M. Bear, Travis E. Faust, Manuel Garber, Christina E. Baer, Dorothy P. Schafer, Zhiping Weng, Fei Chen, Evan Z. Macosko & Paul L. Greer
Nature Neuroscience (2022)
The olfactory system’s ability to detect and discriminate between the vast array of chemicals present in the environment is critical for an animal’s survival. In mammals, the first step of this odor processing is executed…
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Publications
Jonathan Liu, Vanessa Tran, Venkata Naga Pranathi Vemuri, Ashley Byrne, Michael Borja, Snigdha Agarwal, Ruofan Wang, Kyle Awayan, Abhishek Murti, Aris Taychameekiatchai, Bruce Wang, George Emanuel, Jiang He, John Haliburton, Angela Oliveira Pisco, Norma Neff
bioRxiv doi:10.1101/2022.03.04.483068
Spatial transcriptomics extends single cell RNA sequencing (scRNA-seq) technologies by providing spatial context for cell type identification and analysis. In particular, imaging-based spatial technologies such as Multiplexed Error-Robust Fluorescence In Situ Hybridization (MERFISH) can achieve…
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Publications
George Emanuel & Jiang He
Microscopy Today (2021)
The structure and organization of cells within organs is essential to their function, but nowhere in the body is this more spectacular than the brain. There, sprawling, snowflake-like neurons have grown into a precise arrangement,…
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Publications
Biological systems are comprised of numerous cell types, intricately organized to form functional tissues and organs. Building molecular atlases to fully understand the structure and function of each cell within the brain is now a…
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Product Literature
MERSCOPE™ Platform product details.
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Safety Data Sheets
Safety Data Sheet for Wash Buffer 2, BULK
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