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Vizgen is developing the next generation of genomics tools to expand on the capabilities of spatially resolved transcriptomics. Our technology will aide the acceleration of biological research and discovery to advance human health. Access supporting resources by selecting the category below.

Publications

SFN 2022 Poster: Analyzing the molecular basis underlying anatomic and functional complexity of the mouse brain with MERSCOPE™

Renchao Chen, Cheng-Yi Chen, Nicolas Fernandez, Bin Wang, Yuan Cai, Leiam Colbert, Jiang He

Single-cell sequencing has provided numerous novel insights into cell heterogeneity and cell-type-specific adaptation of the nervous system. However, most sequencing-based techniques require cell dissociation and consequently lose the spatial information of the analyzed cells, which…

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Publications

SFN 2022 Poster: True multiomic in situ single-cell imaging revealed massive pathological changes in Alzheimer’s disease brain

Bin Wang, Yijia Sun, Renchao Chen, Timothy Wiggin, Nicolas Fernandez, Yuan Cai, Yi Sun, George Emanuel, Jiang He

Our understanding of molecular biology and pathology has been greatly facilitated by recent advances in multiple sequencing technologies, coupled with computational analysis, to detect and count proteins and transcripts. However, these tools lack spatial resolution…

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Publications

Omics goes spatial epigenomics

Florian Schueder, Joerg Bewersdorf
CellPress

Spatial omics techniques generate spatially resolved, comprehensive data about molecules that define the identity and function of cells in tissues. Epigenetic multiplexing approaches such as Multiplexed Error-robust FISH (MERFISH), introduced by Lu et al. in this…

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Publications

AGBT 2022 Poster: In Situ Single-cell Transcriptomic Imaging in Formalin-fixed Paraffin-embedded Tissues with MERSCOPETM

Jiang He, Lizhi He, Timothy Wiggin, Alex S Genshaft, Rob Foreman, Natalia Petrenko, Nicholas Fernandez, Renchao Chen, Colles Price, George Emanuel

Formalin-fixed paraffin-embedded (FFPE) tissues are widely used clinical sample types for histology and molecular diagnosis. However, due to RNA degradation and protein cross-linking, FFPE samples are often challenging for single-cell transcriptomic analysis. Vizgen’s in situ…

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Publications

Comparative analysis of MERFISH spatial transcriptomics with bulk and single-cell RNA sequencing

Jonathan Liu, Vanessa Tran, Venkata Naga Pranathi Vemuri, Ashley Byrne, Michael Borja, Snigdha Agarwal, Ruofan Wang, Kyle Awayan, Abhishek Murti, Aris Taychameekiatchai, Bruce Wang, George Emanuel, Jiang He, John Haliburton, Angela Oliveira Pisco, Norma Neff
bioRxiv doi:10.1101/2022.03.04.483068

Spatial transcriptomics extends single cell RNA sequencing (scRNA-seq) technologies by providing spatial context for cell type identification and analysis. In particular, imaging-based spatial technologies such as Multiplexed Error-Robust Fluorescence In Situ Hybridization (MERFISH) can achieve…

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Publications

Spatial transcriptomic reconstruction of the mouse olfactory glomerular map suggests principles of odor processing

I-Hao Wang, Evan Murray, Greg Andrews, Hao-Ching Jiang, Sung Jin Park, Elisa Donnard, Violeta Durán-Laforet, Daniel M. Bear, Travis E. Faust, Manuel Garber, Christina E. Baer, Dorothy P. Schafer, Zhiping Weng, Fei Chen, Evan Z. Macosko & Paul L. Greer
Nature Neuroscience (2022)

The olfactory system’s ability to detect and discriminate between the vast array of chemicals present in the environment is critical for an animal’s survival. In mammals, the first step of this odor processing is executed…

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Application & Technical Notes

Protein Co-Detection with MERSCOPE

Abstract: Spatially resolved transcriptomic imaging technologies such as Vizgen’s MERSCOPE TM platform allows massively multiplexed single-cell measurement in situ and have been instrumental for molecular and cell atlasing. However, cell types and states are not only…

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