Explore new dimensions with MERSCOPE™, the first high multiplexing, high resolution in situ platform to combine single-cell and spatial genomics analysis powered by MERFISH technology.
We integrated MERFISH technology with high resolution imaging, fluidics, image processing, and automation to deliver a complete end-to-end spatial genomics solution. The MERSCOPE Platform comes with everything your lab needs to get running. We built our expertise into every component of the system so you can easily obtain and analyze high quality MERFISH measurements.
The MERSCOPE Platform is comprised of:
Through combinatorial labeling, sequential imaging, and error-robust barcoding, MERFISH technology provides the highest detection efficiency and resolution available for spatially profiling the transcriptome, from whole tissue section to single-cell and finally sub-cellular imaging across the whole tissue. We are proud to offer a Data Release Program to provide researchers with public access to MERSCOPE-generated data.
MERSCOPE uses MERFISH technology to directly map and quantify the spatial distribution of hundreds to tens of thousands of RNA species in individual cells, without the need for downstream sequencing. The instrument is comprised of an imaging box and a processing computer.
Detect low expressing genes that can be missed using other technologies.
Localize RNA transcripts at a subcellular level with ≤100 nm resolution.
High multiplexing with custom gene panel design. Current chemistry up to 500 genes.
Measure your specified genes on many sample or tissue types.
Intuitive automation and complete reagent packs allow for a walk-away system.
The Vizgen Gene Panel Portal is a user-friendly web-based application for building custom gene panels to run on the MERSCOPE™ Platform. With the Portal you can customize your gene panels with real-time feedback about which genes are most suitable for a MERFISH measurement. The Portal guides you through each step, making the entire process simple and easy.
From the Portal you can:
The MERSCOPE™ Vizualizer software enables users to interact, analyze, and interpret even the most complex datasets generated by a MERFISH experiment. Our intuitive software seamlessly combines spatial context at the single-cell level to assist researchers with gaining valuable biological insights. With the tool, you can easily visualize MERFISH data including:
| Product | Description |
|---|---|
| MERSCOPE Slides | Sample slides for MERSCOPE instrument that are functionalized for tissue samples to enable Vizgen sample preparation protocols. |
| MERSCOPE Gene Panels | Custom gene panels comprised of encoding probes targeting. Currently available in three sizes; up 140 genes, up to 300 genes and up to 500 genes. |
| MERSCOPE Gene Imaging Kits | Imaging reagent kits containing the reagents and cartridge for running a measurement on the MERSCOPE platform. Currently available in three sizes; up 140 genes, up to 300 genes and up to 500 genes. |
| MERSCOPE Cell Boundary Staining Kit | Kit containing a 3-protein staining reagent for cell segmentation in dense tissues. Compatible with Human and Mouse samples. |
| MERSCOPE Sample Prep Kit | Kit containing sample preparation reagents for 20 samples. Compatible with fixed, fresh frozen tissue and cultured cells. |
| MERSCOPE Sample Verification Kit | Kit containing smFISH probes and imaging reagents to do a single imaging run. Currently available for human and mouse. |
If you are interested in using MERSCOPE for your research, click here to contact us today.