A multiplex immunofluorescence assay to assess immune checkpoint inhibitor targeted CD8 activation and tumor co-localization in FFPE tissues Copy

Immune checkpoint inhibitors promote antitumor immune responses by enhancing T-cell activity.Measuring the pharmacodynamic effects of these drugs is challenging, as it requires assessing both immune cell andcancer cell populations. To evaluate T-cell activation in tumor tissue from patient biopsies, we developed a robustmultiplexed immunofluorescence assay. Presented at ASCO 2019.