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Vizgen is developing the next generation of genomics tools to expand on the capabilities of spatially resolved transcriptomics. Our technology will aide the acceleration of biological research and discovery to advance human health. Access supporting resources by selecting the category below.


How MERFISH Technology Works

Learn how Multiplexed Error-Robust Fluorescence in situ Hybridization (MERFISH) technology works. MERFISH is a spatially resolved single-cell transcriptome profiling technology. MERFISH combines the power of single-cell transcriptomics with spatial biology by directly visualizing and counting…

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Spatial transcriptomic reconstruction of the mouse olfactory glomerular map suggests principles of odor processing

I-Hao Wang, Evan Murray, Greg Andrews, Hao-Ching Jiang, Sung Jin Park, Elisa Donnard, Violeta Durán-Laforet, Daniel M. Bear, Travis E. Faust, Manuel Garber, Christina E. Baer, Dorothy P. Schafer, Zhiping Weng, Fei Chen, Evan Z. Macosko & Paul L. Greer
Nature Neuroscience (2022)

The olfactory system’s ability to detect and discriminate between the vast array of chemicals present in the environment is critical for an animal’s survival. In mammals, the first step of this odor processing is executed…

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Comparative analysis of MERFISH spatial transcriptomics with bulk and single-cell RNA sequencing

Jonathan Liu, Vanessa Tran, Venkata Naga Pranathi Vemuri, Ashley Byrne, Michael Borja, Snigdha Agarwal, Ruofan Wang, Kyle Awayan, Abhishek Murti, Aris Taychameekiatchai, Bruce Wang, George Emanuel, Jiang He, John Haliburton, Angela Oliveira Pisco, Norma Neff
bioRxiv doi:10.1101/2022.03.04.483068

Spatial transcriptomics extends single cell RNA sequencing (scRNA-seq) technologies by providing spatial context for cell type identification and analysis. In particular, imaging-based spatial technologies such as Multiplexed Error-Robust Fluorescence In Situ Hybridization (MERFISH) can achieve…

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SFN 2021 Poster: Molecular Atlassing with MERSCOPE

Biological systems are comprised of numerous cell types, intricately organized to form functional tissues and organs. Building molecular atlases to fully understand the structure and function of each cell within the brain is now a…

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