Omics goes spatial epigenomics

Florian Schueder, Joerg Bewersdorf

Spatial omics techniques generate spatially resolved, comprehensive data about molecules that define the identity and function of cells in tissues. Epigenetic multiplexing approaches such as Multiplexed Error-robust FISH (MERFISH), introduced by Lu et al.

in this issue of Cell, now allows researchers to study the epigenomic regulation of gene expression in a tissue-region specific manner.