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Verify each antibody of interest does not have RNase contamination Determine antibody specificity and concentration using immunofluorescence (IF) imaging. Use the appropriate MERSCOPE Protein Stain Verification Kit to confirm by visual inspection that protein staining…

Overview: To generate the best data possible using our MERSCOPE Platform, researchers must ensure they are working with high-quality RNA samples. Unfortunately, RNA is easily degraded by RNases when samples are mishandled or treated in…

Abstract: Spatially resolved transcriptomic imaging technologies such as Vizgen’s MERSCOPE TM platform allows massively multiplexed single-cell measurement in situ and have been instrumental for molecular and cell atlasing. However, cell types and states are not only…

Abstract: Formalin fixed-paraffin-embedded (FFPE) tissue processing remains the most economical approach for archivable tissue specimen storage. Therefore, the ability to apply high throughput genomic applications to FFPE specimens can expand clinical assays and discovery. While…

Abstract: MERFISH technology is based on single molecule fluorescence in situ hybridization (smFISH) and can measure both the copy number and spatial distribution of 100s to 1000s of RNAs simultaneously.1 However, the RNA in fresh…

This technical note describes a MERSCOPE sample preparation protocol for cultured cells without the gel embedding steps, which simplifies the standard workflow and shortens the protocol by one day without compromising data quality. Additional sample…

A New Spatial Transcriptomics Technique Accurately Reveals the Organization of The Mouse Brain Transcriptome This application note describes how the MERFISH Mouse Brain Receptor map was generated by MERSCOPE and demonstrates how the platform can…